135 articles - From Friday Jul 08 2022 to Friday Jul 15 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
| Endoscopy |
Reducing the environmental footprint of gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Gastroenterology and Endoscopy Nurses and Associates (ESGENA) Position Statement. 9: ESGE-ESGENA recommend that GI endoscopy companies assess, disclose, and audit the environmental impact of their value chain. 10: ESGE-ESGENA recommend that GI endoscopy should become a net-zero greenhouse gas emissions practice by 2050. |
| Gut |
British Society of Gastroenterology guidelines on the management of functional dyspepsia. These provide both the strength of the recommendations and the overall quality of evidence. Finally, in this guideline, we consider novel treatments that are in development, as well as highlighting areas of unmet need and priorities for future research. |
Faecal immunochemical testing (FIT) in patients with signs or symptoms of suspected colorectal cancer (CRC): a joint guideline from the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and the British Society of Gastroenterology (BSG). In order to achieve consensus among a broad group of key stakeholders, we completed an extended Delphi of the GDG, and also 61 other individuals across the UK and Ireland, including by members of the public, charities and primary and secondary care. Seventeen research recommendations were also prioritised to inform clinical management. |
meta-analyses and systematic reviews
| Endoscopy |
Long-Term Outcomes of Per-Oral Endoscopic Myotomy (POEM) for Achalasia: a Systematic Review and Meta-analysis. Long-term clinical efficacy of POEM persists in nearly 87% of patients with achalasia. Post-POEM symptomatic reflux seems to remain stable over time. Risk for Barrett's esophagus and peptic strictures appears minimal. |
| Gastrointest Endosc |
A SYSTEMATIC REVIEW AND META-ANALYSIS OF SAFETY AND EFFICACY OF OVER THE SCOPE CLIPS VERSUS STANDARD THERAPY FOR HIGH-RISK NON-VARICEAL UPPER GASTROINTESTINAL BLEEDING. While our study is limited to high-risk NVUGIB's, our analysis shows that hemostasis with OTSC is associated with a lower 7-day and 30-day rebleeding rate, higher clinical success rates and shorter procedure time with similar mortality rates and length of hospital stay as compared to standard therapy. |
RCT, clinical trials, retrospective studies, etc…
| Clin Gastroenterol Hepatol |
Artificial Intelligence allows Leaving-in-Situ colorectal polyps. In this study, CADx without advanced imaging exceeded the benchmarks required for optical diagnosis of colorectal polyps. CADx could help implement cost-saving strategies in colonoscopy by reducing the burden of polypectomy and/or pathology. |
Risk of fractures and subsequent mortality in alcohol-related cirrhosis: A nationwide population-based cohort study. Alcohol-related cirrhosis is associated with an almost fourfold increased fracture rate, a higher risk of fractures the first two decades after initial diagnosis, and higher post-fracture mortality. Preventive interventions to reduce modifiable fracture risk factors in this population are justified. |
The prevalence and determinants of NAFLD and MAFLD and their severity in the VA primary care setting. NAFLD was present in 40% of veterans registered in primary care; 9.4% of Veterans had at least moderate hepatic fibrosis, with most having concurrent NAFLD. There was perfect concordance between NAFLD and the alternative MAFLD definition. |
Trends in Etiology-based Mortality from Chronic Liver Disease before and during COVID-19 Pandemic in the United States. All-cause mortality for ALD and NAFLD rapidly accelerated during the COVID-19 pandemic compared to the pre-COVID-19 era. There has been a significant decline in viral hepatitis; however, a significant increase in COVID-related death in this population. |
| Endoscopy |
Nasal breathing is superior to oral breathing in performing and undergoing transnasal endoscopy: a randomized trial. Nasal breathing is superior to oral breathing in performing and undergoing transnasal endoscopy. Nasal breathing led to good visibility of the upper-middle pharynx, improved endoscopic operability and patient tolerance, and showed safety by decreasing pharyngeal bleeding. |
Pre-resection biopsy of large non-pedunculated colorectal polyps does not reliably detect advanced dysplastic change and may increase complexity of endoscopic mucosal resection. Routine PRB of LNPCP does not reliably detect advanced histology, and may affect EMR complexity. PRB should be utilised with caution in guiding endoscopic management of LNPCPs. |
Small-sized versus standard magnetic capsule endoscopy in adults: a two-center, double-blinded randomized controlled trial. In the small-sized MCE group, the mean (SD) difficulty score and time to swallow the capsule, and success rate for swallowing the capsule at the first attempt were 0.6 (1.0), 3.4 (1.3) seconds, and 89.6 |
| Gastroenterology |
Biogeographic variation and functional pathways of the gut microbiota in celiac disease. We identify novel microbial proteolytic pathways involved in gluten detoxification that are impaired in CeD, but not in controls carrying DQ2, suggesting association with active duodenal inflammation. Sampling site should be considered a cofounding factor in microbiome studies in CeD. |
Using Human Induced Pluripotent Stem Cell Derived Organoids to Identify New Pathologies in Patients with PDX1 Mutations. These patients will now be monitored for the progression of metaplasia and gastrointestinal complications that might be related to the reduced gastric and intestinal endocrine cells. This study demonstrates the utility of organoids in diagnosing uncovered pathologies. |
| Gastrointest Endosc |
Improving 30-day mortality following percutaneous endoscopic gastrostomy tube placement in England from 2007 to 2019: a retrospective national cohort analysis of 87,862 patients. 30 day mortality following PEG insertion has fallen 60% over 13 years. Dementia or stroke as a PEG indication fell and the time interval from stroke to PEG insertion increased. These findings may be attributable to improved patient selection and timing for PEG insertion. |
Tip-in Endoscopic Mucosal Resection as an Alternative to Endoscopic Submucosal Dissection for 20-30-mm Non-Pedunculated Colorectal Neoplasms. Tip-in EMR is comparable to ESD with respect to the local recurrence rate but has a shorter procedure time, despite the lower en bloc and R0 resection rate for 20-30-mm non-pedunculated colorectal neoplasms without fold convergence or non-lifting sign. Thus, Tip-in EMR could be a feasible alternative to ESD in these lesions. |
| Gut |
A novel peptide protects against diet-induced obesity by suppressing appetite and modulating the gut microbiota. Our results indicated that D3 is a novel drug candidate for counteracting diet-induced obesity as a non-toxic and bioactive peptide. Targeting the UGN-GUCY2C endocrine axis may represent a therapeutic strategy for the treatment of obesity. |
Accurate liquid biopsy for the diagnosis of non-alcoholic steatohepatitis and liver fibrosis. The proposed novel liquid biopsy is accurate, sensitive and specific in diagnosing the presence and severity of NASH or liver fibrosis and is more reliable than currently used biomarkers. Clinical trials Discovery multicentre cohort Bariatric Surgery versus Non-Alcoholic Steatohepatitis, BRAVES, ClinicalTrials.gov identifier NCT03524365.Validation multicentre cohort Liquid Biopsy for NASH and Fibrosis, LIBRA, ClinicalTrials.gov identifier NCT04677101. |
Methionine deficiency facilitates antitumour immunity by altering m6A methylation of immune checkpoint transcripts. Methionine and YTHDF1 play a critical role in anticancer immunity through regulating the functions of T cells. Targeting methionine metabolism or YTHDF1 could be a potential new strategy for cancer immunotherapy. |
Regulatory enhancer profiling of mesenchymal-type gastric cancer reveals subtype-specific epigenomic landscapes and targetable vulnerabilities. Our results establish a consensus Mes-GC classifier applicable to multiple transcriptomic scenarios. Mes-GCs exhibit a distinct epigenomic landscape, and TEAD1 inhibition and combinatorial NUAK1 inhibition/cisplatin may represent potential targetable options. |
| Hepatology |
Machine Learning Models Are Superior to Non-Invasive Tests in Identifying Clinically Significant Stages of NAFLD and NAFLD-Related Cirrhosis. ML models performed better overall than FibroScan®, FIB-4, FAST, and NFS. ML could be an effective tool for identifying clinically significant liver fibrosis and cirrhosis in NAFLD patients. |
Next Generation Pathology Detection of T cell-Antigen Presenting Cell Immune Synapses in Human Liver Allografts. NGP-detected ai-SYN (subpathological rejection) in LTx patients prior to immunosuppression reduction suggests that NGP-detected (allo)immune activity usefulness for titration of immunosuppressive therapy in various settings. |
RNA helicase DEAD-box protein 5 alleviates nonalcoholic steatohepatitis progression via tethering TSC complex and suppressing mTORC1 signaling. These findings provide new mechanistic insight into the role of DDX5 in mTORC1 regulation and NASH progression, as well as suggest a number of new targets and a promising lead compound for therapeutic interventions against NASH. |
Sociodemographic and geographic differences in the U.S. epidemiology of autoimmune hepatitis with and without cirrhosis. AIH epidemiology differs according to sociodemographic and geographic factors in the U.S. Studies are needed to determine the genetic, epigenetic and environmental factors underlying the heterogeneity in AIH risk and outcomes. |
| Inflamm Bowel Dis |
Comparative Acceptability of Therapeutic Maintenance Regimens in Patients With Inflammatory Bowel Disease: Results From the Nationwide ACCEPT2 Study. Although oral intake is overall preferred, acceptability is highly impacted by the rhythm of administration and prior medication exposures. However, SC treatment with long intervals between 2 injections (=8 weeks) and oral intake once daily seems to be the most accepted modalities. |
Etrolizumab-s Does Not Induce Residual Trafficking of Regulatory T Cells. Etrolizumab does not seem to induce notable residual trafficking of Treg cells. Thus, the Teff overweight in the inflamed gut might persist despite reduced overall T cell recruitment. This might be one piece of the puzzle to explain recent clinical results in phase 3. |
Examination Under Anesthesia May Not Be Universally Required Prior to Anti-TNF Therapy in Perianal Crohn's Disease: A Comparative Cohort Study. EUA before anti-TNF therapy was not associated with improved clinical outcomes compared with anti-TNF therapy alone, suggesting that EUA may not be universally required. Future prospective studies controlling for fistula severity are warranted. |
New Pneumococcal Vaccines for Prevention of Invasive Pneumococcal Disease in Adult Patients With Inflammatory Bowel Disease. Previous studies have shown that pneumococcal vaccination can decrease the risk of developing severe pneumococcal disease; therefore, it is important that patients with IBD receive pneumococcal vaccination. This report aims to inform clinicians who care for patients with IBD about the changes in immunization practices, as it pertains to pneumococcal vaccination and provides appropriate direction on administering vaccination series. |
The Current State of Care for Black and Hispanic Inflammatory Bowel Disease Patients. In this comprehensive review, we examine the epidemiology, clinical presentations, disease phenotypes, treatment outcomes, social determinants of health, and genetic and environmental factors in the pathogenesis of IBD in Black and Hispanic patients in the United States. To improve health equity of underserved minorities with IBD, we identified the following priority areas: access to care, accurate assessment of treatment outcomes, incorporation of Black and Hispanic patients in therapeutic clinical trials, and investigation of environmental factors that lead to the increase in disease incidence. |
| J Crohns Colitis |
CD147 Targeting by AC-73 Induces Autophagy and Reduces Intestinal Fibrosis Associated with TNBS Chronic Colitis. CD147 is a potential new target for controlling intestinal fibrosis and its inhibitor, AC-73, might represent a potential new anti-fibrotic therapeutic option in IBD. |
Segmental versus total colectomy for Crohn's disease in the biologic era. Results from The SCOTCH international, multicentric study. When technically feasible, SC is safe and reduces temporary and permanent stoma. Young age, number of locations, and perianal disease adversely affects, but postoperative biologicals therapy significantly reduces, the long-term surgical recurrence. |
| J Hepatol |
Inflammatory type 2 conventional dendritic cells contribute to murine and human cholangitis. Cholangitis is characterised by intrahepatic expansion and inflammatory maturation of type 2 conventional dendritic cells in response to biliary injury. Therefore, type 2 conventional dendritic cells and their inflammatory mediators might be potential therapeutic targets for the treatment of PSC. |
Risk of acute liver injury following the mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccines. There was no evidence of an increased risk of ALI associated with BNT162b2 or CoronaVac vaccination. Based on al current available evidence from previous studies and our study, the benefit of mass vaccination far outweighs the ALI risk from vaccination and SARS-CoV-2 infection. |
Vitamin B12 and folate decrease inflammation and fibrosis in NASH by preventing Syntaxin 17 homocysteinylation. Methods We examined the effects of HHcy on NASH progression, metabolism, and autophagy in dietary and genetic mouse models, patients, and primates. We employed vitamin B and folate supplementation restored autophagy and reduced NASH progression and could be a new first-line therapy for NASH. |
| J Neurogastroenterol Motil |
Saccharomyces boulardii and Lactulose for Childhood Functional Constipation: A Multicenter Randomized Controlled Trial. Methods This open-label randomized controlled trial was conducted at 10 university hospitals in Korea. Children who were diagnosed with functional constipation were allocated to 3 groups (lactulose monotherapy, combination therapy, and monotherapy was not superior to lactulose monotherapy or combination therapy and showed a higher drug change rate, supporting the current recommendation of probiotics in the treatment of childhood functional constipation. |
A Potential Role of Cholinergic Dysfunction on Impaired Colon Motility in Experimental Intestinal Chagas Disease. Background/aims Chagasic megacolon is caused by -induced damage of smooth muscles was accompanied by motility disorders such as decreased intestinal peristalsis and cholinergic system response impairment. This study allows integration of the natural history of Chagasic megacolon motility disorders and opens new perspectives for the design of effective therapeutic. |
Association Between Eating Behavior, Frequency of Meals, and Functional Dyspepsia in Young Japanese Population. In the young Japanese people, the frequency of meals may be independently inversely associated with prevalence of FD. In particular, skipping breakfast and/or lunch was associated with the prevalence of FD. |
Association Between Gut Regulatory Hormones and Post-operative Weight Loss Following Gastrectomy in Patients With Gastric Cancer. Significant weight reduction was common after subtotal gastrectomy for gastric cancer with a negative correlation pre-operative plasma ghrelin levels. Incretin hormones are modestly but significantly increased after subtotal gastrectomy; however, these changes did not affect the weight changes. |
Efficacy of Slow Nutrient Drinking Test for Evaluating Postprandial Distress Symptom in Japanese Patients With Functional Dyspepsia. The 30-minute slow nutrient drinking test is a minimally invasive method of effectively evaluating symptoms of postprandial distress syndrome among patients with FD, in Japan. |
General Well-being and Coping Strategies in Adult Eosinophilic Esophagitis Patients. EoE has a significant negative impact on mental HRQOL, with less effective coping strategies--specifically in males, being a relevant determinant. Thus, a pro-active approach towards coping mechanisms is needed in order to enhance HRQOL and manage patients' burden of EoE. |
Normal Values of High-resolution Anorectal Manometry of Healthy Indians. The present study provides normal data for the Indian population that can be used for comparison and further work. Age, gender, and BMI affect anorectal parameters in HRAM and should be considered while reporting. |
Risk Factors for Self-reported Irritable Bowel Syndrome With Prior Psychiatric Disorder: The Lifelines Cohort Study. Despite its limitations this study suggests that prior psychiatric disorder is an important risk factor in a quarter of IBS onsets. Negative health perception and multiple bodily symptoms are associated with al IBS onsets in line with the cognitive-behavior model of IBS. Prior psychiatric disorder may predict an optimal response to psychiatric treatment. Further studies could usefully study mechanisms linking IBS to prior psychiatric disorder. |
Safety and Efficacy of Elobixibat, an Ileal Bile Acid Transporter Inhibitor, in Elderly Patients With Chronic Idiopathic Constipation According to Administration Time: Interim Analysis of Post-marketing Surveillance. The results suggested that elobixibat was well-tolerated and efficacious in elderly patients with chronic constipation and can be administered before any meals. |
The Predictive Value of Intraoperative Esophageal Functional Luminal Imaging Probe Panometry in Patients With Achalasia Undergoing Peroral Endoscopic Myotomy: A Single-center Experience. While FLIP panometry was not significantly associated with the clinical course of achalasia, FLIP panometry was associated with POC following POEM and may complement manometry in the functional evaluation of esophageal motility disorders. |
The Upper Esophageal Sphincter Distensibility Index Measured Using Functional Lumen Imaging Probe Identifies Defective Barrier Function of the Upper Esophageal Sphincter. A higher UES-DI measures defective barrier function which could may be the main pathophysiology that generates supra-esophageal symptoms. |
| Neurogastroenterol Motil |
A prospective study of intrapyloric botulinum toxin and EndoFLIP in children with nausea and vomiting. The majority of patients responded to IPBI, with significant improvements seen in nausea, vomiting, and discomfort. Pyloric EndoFLIP tended to distinguish baseline delays in gastric emptying, but it did not predict IPBI response in this patient cohort. |
Virtual Tai Chi program for patients with irritable bowel syndrome with constipation: Proof-of-concept feasibility trial. Our data provide preliminary evidence of the feasibility of a Tai Chi intervention for IBS-C, show promise for improving outcomes, and identify more streamlined data collection as an area for further program improvement. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
Review article: Becoming and being coeliac-special considerations for childhood, adolescence and beyond. Childhood and adolescence carry unique issues pertaining to the diagnosis and management of coeliac disease, and include nutrition and growth, rescreening, repeat biopsy, dietary adherence concerns and transition to adult care. In conclusion, while coeliac disease has similar pathogenesis and general clinical manifestations in paediatric and adult populations, diagnostic and management approaches need to adapt to the developmental stages. |
Review article: Diagnosis of coeliac disease: a perspective on current and future approaches. Non-biopsy diagnosis may expand further because research methods for measuring gluten-specific CD4+ T cells and the acute recall response to gluten ingestion in patients is now relatively straightforward. This perspective on diagnosis in the context of the immunopathogenesis of coeliac disease sets out to highlight current consensus, limitations of current practices, gluten food challenge for diagnosis and the potential for diagnostics that measure the underlying cause for coeliac disease, gluten-specific immunity. |
Review article: Dietary management of coeliac disease. There are many barriers to dietary adherence including increased cost and limited availability of gluten-free products, as well as the negative impact on an individual's social domain of quality of life. Therefore, assessment, education and counselling by a coeliac specialist dietitian should be the cornerstone of dietary management. |
Review article: Epidemiology of coeliac disease. In addition to genetic factors, while there are many environmental risk factors, including age at the first introduction of gluten, breastfeeding, caesarean section, exposure to antibiotics and gut microbiome; the amount of gluten ingestion during early part of life, however, has been shown to increase the risk of coeliac disease, and this is relevant from the point of view of primary prevention. In this review, we have reviewed and summarised the literature, up till year 2021, related to the global and continent-wise epidemiology and risk factors associated with coeliac disease. |
Review article: Follow-up of coeliac disease. Effective models of care involving the gastroenterologist, dietitian and primary care doctor will improve the consistency of long-term management and likely translate into better patient outcomes. Identifying suitable treatment targets linked to long-term health is an important goal. |
Review article: Systemic consequences of coeliac disease. The various systemic consequences of coeliac disease play a significant role in the overall health of patients. Early diagnosis and treatment with a gluten-free diet appear to be beneficial for most, but not al of these conditions. The possible negative metabolic and psychosocial effects of the diet should be acknowledged during follow-up. |
| Gastroenterology |
| Gut |
Cancer as microenvironmental, systemic and environmental diseases: opportunity for transdisciplinary microbiomics science. Ideally, a prospective cohort study design that enables biospecimen (such as stool) collection before disease detection should be considered to address reverse causation and recall biases. Robust experimental and observational research together can provide insights into dynamic interactions between environmental exposures, microbiota, tumour and immunity during carcinogenesis processes, thereby helping us develop precision prevention and therapeutic strategies to ultimately reduce the cancer burden. |
| Hepatology |
| J Hepatol |
COVID-19 positive donor for solid organ transplantation. As the evolving outbreak of SARS-CoV-2 continues, alongside the presence of vaccines and new treatment options, clinicians should consider transplanting organs from deceased donors with active SARS-CoV-2 infection to recipients with limited opportunities for transplantation and natural or vaccine induced specific immunity. This article seeks to describe an expert opinion for the use of organs from deceased donors with resolved or active SARS-CoV-2 infection in the absence of more definitive data and standardized acceptance patterns. |
Exotic viral hepatitis; a review on epidemiology, pathogenesis, and treatment. Therapy for exotic viral hepatitis is predominantly supportive. To ensure that preventive measures can be introduced to control possible outbreaks, the timely detection of these viruses is very important. |
| J Neurogastroenterol Motil |
How to Implement the 3-Phase FODMAP Diet Into Gastroenterological Practice. While the diet has shown improved irritable bowel syndrome outcomes across studies, it is important to acknowledge the essential role of dietitians in implementing, tailoring, and managing the diet to achieve the best outcome for each individual. |
| Neurogastroenterol Motil |
Orthorexia nervosa is a concern in gastroenterology: A scoping review. Clinicians should consider if a restrictive diet is appropriate for individuals with DGBI and include screening for disordered eating prior to implementation of dietary modifications. Future prospective studies should evaluate orthorexia within this patient group. |
The Rome Foundation Global Epidemiology study: Research opportunities national and worldwide. The questionnaire in Israel was available to the participants online in four different languages used by the population in Israel: The database of the study is now available through the Rome Foundation Research Institute for use by academic and industry researchers. This unique gift from the Rome Foundation to the scientific community no doubt will further enhance our understanding of disorders of gut-brain interaction. |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
| Clin Gastroenterol Hepatol |
| Gastroenterology |
Failure to Achieve Target Drug Concentrations During Induction and Not HLA-DQA1*05 Carriage is Associated with Anti-Drug Antibody Formation in Patients with Inflammatory Bowel Disease: HLA-DQA1*05 Testing for Immunogenicity to anti-TNF Remains Relevant in IBD, But Depends on Therapeutic Drug Monitoring Strategy. |
| Gut |
| Hepatology |
| J Hepatol |
| J Neurogastroenterol Motil |
all remaining publications eg case reports, images of the month, etc…
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastroenterology |
| Gut |
| Inflamm Bowel Dis |
| J Crohns Colitis |